Suppression of Ribosome Biogenesis by Targeting WD Repeat Domain 12 (WDR12) Inhibits Glioma Stem-Like Cell Growth

Glioma stem-like cells (GSCs) are a subset of tumor cells that initiate malignant growth and promote the therapeutic resistance nicabate patches of glioblastoma, the most lethal primary brain tumor.Ribosome biogenesis is an essential cellular process to maintain cell growth, but its regulatory mechanism in GSCs remains largely unknown.Here, we show

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A three-dimensional variational data assimilation system for aerosol optical properties based on WRF-Chem v4.0: design, development, and application of assimilating Himawari-8 aerosol observations

This paper presents a three-dimensional variational (3DVAR) data assimilation (DA) system for aerosol optical properties, including aerosol optical thickness (AOT) retrievals and lidar-based aerosol profiles, developed for the Model for Simulating Aerosol Interactions and Chemistry (MOSAIC) within the Weather Research and Forecasting model coupled

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Comparative analysis of iron homeostasis in sub-Saharan African children with sickle cell disease and their unaffected siblings

Iron is an essential trace element subject to tight regulation to ensure adequate running of biological processes.In sub-Saharan Africa where hemoglobinopathies are common, iron homeostasis is likely to be impaired by these conditions.Here we assessed and compared key serum proteins associated with iron metabolism between sub-Saharan African childr

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Postnatal oogenesis in humans: a review of recent findings

Irma Virant-Klun Department of Obstetrics and Gynaecology, University Medical Center Ljubljana, Ljubljana, Slovenia Abstract: In spite of generally accepted dogma that the total number of follicles and oocytes is established in human ovaries during the fetal period of life rather than forming de novo in adult ovaries, some new evidence in the field

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